![]() Local and systemic inflammation induced by obesity or type 2 diabetes mellitus can cause BBB breakdown, decreased removal of waste, and increased infiltration of immune cells. The BBB, a system designed to restrict entry of toxins, immune cells, and pathogens to the brain, is vital for proper neuronal function. Neuropathologies triggered by metabolic syndrome often result from increased permeability of the blood–brain-barrier (BBB). It induces systemic inflammation, causing far reaching effects on the body that are still being uncovered. Metabolic syndrome, which includes diabetes and obesity, is one of the most widespread medical conditions. 3Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.2Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. ![]() 1Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.Peter Van Dyken 1 and Baptiste Lacoste 1,2,3* ![]()
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